Gynecologic Oncology Trials

NRG Oncology is a non-profit research organization formed to conduct oncologic clinical research and to broadly disseminate study results for informing clinical decision making and healthcare policy. It brings together the National Surgical Adjuvant Breast and Bowel Project (NSABP), the Radiation Therapy Oncology Group (RTOG), and the Gynecologic Oncology Group (GOG)—each recognized internationally as a research leader.

NRG Oncology embodies an impressive legacy in the conduct of multi-institutional phase II and phase III clinical trials and a history of undertaking phase I and translational biological studies imperative for oncologic research of the future.

These clinical trials are active at any one time for patients with a variety of gynecologic malignancies, including cancers that arise from the ovaries, uterus, cervix, vagina, and vulva. NRG Oncology and the GOG Foundation partner with the Foundation for Women’s Cancer to promote clinical trials participation and provide easy-to-access information about clinical trials that currently are open for enrollment.

Current Gynecologic Oncology Trials:

GOG 0225 Can Diet and Physical Activity Modulate Ovarian or Primary Peritoneal Cancer Progression-Free Survival? (David S Alberts)

GOG 0237 Comparative Analysis of CA-IX, p16, Proliferative Markers, and Human Papilloma Virus (HPV) in the Diagnosis of Significant Cervical Lesions in Patients with a Cytologic Diagnosis of Atypical Glandular Cells (AGC) (Shu-Yuan Liao)

GOG 0238 A Randomized Trial of Pelvic Irradiation with or without Concurrent Weekly Cisplatin in Patients with Pelvic-only Recurrence of Carcinoma of the Uterine Corpus (Higinia R Cardenes)

GOG 0263 Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA, Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphdenectomy. (Sang-Young Ryu)

GOG 0264 A Randomized Phase II Trial of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemo-Naive Sex Cord-Stromal Tumors of the Ovary. (Jubilee Brown)

GOG 0278 Evaluation of Physical Function and QoL Before and After Non-Radical Surgical Therapy for Stage IA1 (LVSI+) and IA2-IB1 Cervical Cancer (NCT# 01649089) (Allan L Covens)

GOG 0279 A Phase II Trial Evaluating Cisplatin and Gemcitabine Concurrent with Intensity-Modulated Radiation Therapy (IMRT) for the Treatment of Locally-Advanced Squamous Cell Carcinoma of the Vulva (NCT# 01595061) (Neil S Horowitz)

GOG 0281 A Randomized Phase II/III Study to Assess the Efficacy of Trametinib (GSK1120212) in Patients with Recurrent or Progressive Low-grade Serous Ovarian Cancer or Primary Peritoneal Cancer (David M Gershenson)

GOG 0286B A Randomized Phase II/III Study of Paclitaxel/Carboplatin/Metformin (NSC#91485) Versus Paclitaxel/Carboplatin/Placebo as Initial Therapy for Measurable Stage III or IVA, Stage IVB, or Recurrent Endometrial Cancer (Victoria L Bae-Jump)

GOG0724 Phase III Randomized Study of Concurrent Chemotherapy and Pelvic RT With or Without Adjuvant Chemotherapy in High-Risk Patients With Early-Stage Cervical Carcinoma Following Radical Hysterectomy (RTOG # 0724) (Heidi J Gray)

GOG 3007 A Randomized Phase II TRIAL of Everolimus and Letrozole or Hormonal Therapy (Tamoxifen/Medroxyprogestrone (Acetate) in Women with Advanced, Persistent, or Recurrent Endometrial Carcinoma (Brian M Slomovitz))

Additional Clinical Trial Resources


Couldn’t make it to the National Race to End Women’s Cancer? You can still support women with gynecologic cancers by making a contribution today.


September is Gynecologic Cancer Awareness Month. #GCAM


The FWC is proud to offer various Research Grants and Awards. Click here for more information.


FREE Gynecologic Cancer Education Courses throughout the country. For more information, click here.