Infection with the human papillomavirus (HPV) is a common cause of vulvar cancer in young patients. Vulvar cancer in older women is associated with a chronic vulvar irritation from any source. Smoking cigarettes increases the risk for vulvar cancer. Infection with the human immunodeficiency virus (HIV). This sexually transmitted virus weakens the immune system, which may make you more susceptible to HPV infections, thereby increasing your risk of vulvar cancer.
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